Birth delivery mode alters perinatal cell death in the mouse brain.

ABSTRACT: Labor and a vaginal delivery trigger changes in peripheral organs that prepare the mammalian fetus to survive ex utero. Surprisingly little attention has been given to whether birth also influences the brain, and to how alterations in birth mode affect neonatal brain development. These are important questions, given the high rates of cesarean section (C-section) delivery worldwide, many of which are elective. We examined the effect of birth mode on neuronal cell death, a widespread developmental process that occurs primarily during the first postnatal week in mice. Timed-pregnant dams were randomly assigned to C-section deliveries that were yoked to vaginal births to carefully match gestation length and circadian time of parturition. Compared with rates of cell death just before birth, vag

SUBMITTER: Castillo-Ruiz A 

PROVIDER: S-EPMC6243246 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature