Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis.

ABSTRACT:

Background and objective

Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. We investigated the association between global genetic ancestry and ON and age at onset of MS in Hispanics.

Methods

Data were obtained for 1033 self-identified Hispanics with MS from four MS-based registries from four academic institutions across the United States January 2016-April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as a

SUBMITTER: Amezcua L 

PROVIDER: S-EPMC6243381 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature