Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To evaluate cerebral degenerative changes in ALS and their correlates with survival using 3D texture analysis.

Methods

A total of 157 participants were included in this analysis from four neuroimaging studies. Voxel-wise texture analysis on T1-weighted brain magnetic resonance images (MRIs) was conducted between patients and controls. Patients were divided into long- and short-survivors using the median survival of the cohort. Neuroanatomical differences between the two survival groups were also investigated.

Results

Whole-brain analysis revealed significant changes in image texture (FDR P < 0.05) bilaterally in the motor cortex, corticospinal tract (CST), insula, basal ganglia, hippocampus, and frontal regions including subcortical white matte

SUBMITTER: Ishaque A 

PROVIDER: S-EPMC6243384 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature