Gated Single-Molecule Transport in Double-Barreled Nanopores.

ABSTRACT: Single-molecule methods have been rapidly developing with the appealing prospect of transforming conventional ensemble-averaged analytical techniques. However, challenges remain especially in improving detection sensitivity and controlling molecular transport. In this article, we present a direct method for the fabrication of analytical sensors that combine the advantages of nanopores and field-effect transistors for simultaneous label-free single-molecule detection and manipulation. We show that these hybrid sensors have perfectly aligned nanopores and field-effect transistor components making it possible to detect molecular events with up to near 100% synchronization. Furthermore, we show that the transport across the nanopore can be voltage-gated to switch on/off translocations in real

SUBMITTER: Xue L 

PROVIDER: S-EPMC6243394 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature