Implication of microglia activation and CSF-1/CSF-1Rpathway in lumbar disc degeneration-related back pain.

ABSTRACT: Back pain is common and costly. Although lumbar disc degeneration has long been regarded as a major contributor to back pain, how disc degeneration leads to back pain remains unclear. Recent studies observed microglia activation in the spinal cord after disc degeneration, suggesting activated microglia may be involved in discogenic back pain. To determine whether microglia activation participates in disc degeneration-induced back pain, we used a modified disc puncture-induced degeneration-related back pain mouse model to examine the changes in spinal microglia and investigate the potential link between microglia activation and discogenic back pain. In this study, 46 CX3CR1^GFP/+ male mice were used in experimental and sham groups. A modified posterolateral retroperitoneal approac

SUBMITTER: Yang G 

PROVIDER: S-EPMC6243401 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature