SYSTOLIC BLOOD PRESSURE INTERVENTION TRIAL: FINDINGS THAT IMPACT OLDER HYPERTENSIVE PATIENTS

ABSTRACT: Abstract Results from the Systolic Blood Pressure Intervention Trial (SPRINT) which compared usual (< 140 mm Hg) with intensive (< 120 mm Hg) SBP targets (ClinicalTrials.gov, NCT01206062) demonstrated that a lower SBP target may be safely recommended for many older patients. SPRINT included 2636 community living subjects aged 75 and older (28% of the entire study population) who were assessed for frailty status including usual gait speed, cognitive function, orthostatic hypotension, and adverse events including injurious falls. In the group of older subjects randomized to the intensive arm there was a 34% reduction in the primary composite CVD outcome and a 33% reduction in all-cause mortality at 3.14 years of follow-up when the trial ended early (numbers needed to treat 27 and 41 respecti

SUBMITTER: Supiano M 

PROVIDER: S-EPMC6243556 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature