CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins.

ABSTRACT: In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

SUBMITTER: Hems ES 

PROVIDER: S-EPMC6243676 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature