Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals.

ABSTRACT: Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta (ERβ) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2⁄DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse ERβ-enhanced BCa cell growth and invasion. Further mechanism dissection found that ERβ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The ERβ up-regulated miR-9

SUBMITTER: Ou Z 

PROVIDER: S-EPMC6243995 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature