Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory symptoms, known as exacerbations. The goal of this pilot study was to test the usefulness of unbiased metabolomics and transcriptomics approaches to delineate biological pathways associated with COPD phenotypes and outcomes. Blood was collected from 149 current or former smokers with or without COPD and separated into peripheral blood mononuclear cells (PBMC) and plasma. PBMCs and plasma were analyzed using microarray and liquid chromatography mass spectrometry, respectively. Statistically significant transcripts and compounds were mapped to pathways using IMPaLA. Results showed that glycerophospholipid metabolism was ass

SUBMITTER: Cruickshank-Quinn CI 

PROVIDER: S-EPMC6244246 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature