Nutritional and meiotic induction of transiently heritable stress resistant states in budding yeast.

ABSTRACT: Transient exposures to environmental stresses induce altered physiological states in exposed cells that persist after the stresses have been removed. These states, referred to as cellular memory, can even be passed on to daughter cells and may thus be thought of as embodying a form of epigenetic inheritance. We find that meiotically produced spores in the budding yeast S. cerevisiae possess a state of heightened stress resistance that, following their germination, persists for numerous mitotic generations. As yeast meiotic development is essentially a starvation response that a/alpha diploid cells engage, we sought to model this phenomenon by subjecting haploid cells to starvation conditions. We find also that haploid cells exposed to glucose withdrawal acquire a state of elevated s

SUBMITTER: Gutierrez H 

PROVIDER: S-EPMC6244294 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature