Guidelines for reporting secondary findings of genome sequencing in cancer genes: the SFMPP recommendations.

ABSTRACT: In oncology, the expanding use of multi-gene panels to explore familial cancer predisposition and tumor genome analysis has led to increased secondary findings discoveries (SFs) and has given rise to important medical, ethical, and legal issues. The American College of Medical Genetics and Genomics published a policy statement for managing SFs for a list of genes, including 25 cancer-related genes. Currently, there are few recommendations in Europe. From June 2016 to May 2017, the French Society of Predictive and Personalized Medicine (SFMPP) established a working group of 47 experts to elaborate guidelines for managing information given on the SFs for genes related to cancers. A subgroup of ethicists, lawyers, patients' representatives, and psychologists provided ethical reflection, infor

SUBMITTER: Pujol P 

PROVIDER: S-EPMC6244405 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature