Impact of a multifaceted prevention program on ventilator-associated pneumonia including selective oropharyngeal decontamination.

ABSTRACT:

Purpose

We describe the impact of a multifaceted program for decreasing ventilator-associated pneumonia (VAP) after implementing nine preventive measures, including selective oropharyngeal decontamination (SOD).

Methods

We compared VAP rates during an 8-month pre-intervention period, a 12-month intervention period, and an 11-month post-intervention period in a cohort of patients who received mechanical ventilation (MV) for > 48 h. The primary objective was to assess the effect on first VAP occurrence, using a Cox cause-specific proportional hazards model. Secondary objectives included the impact on emergence of antimicrobial resistance, antibiotic consumption, duration of MV, and ICU mortality.

Results

Pre-intervention, intervention and post-intervention VAP rates wer

SUBMITTER: Landelle C 

PROVIDER: S-EPMC6244525 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature