Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice.

ABSTRACT: Adult hematopoiesis takes place in the perivascular zone of the bone cavity, where endothelial cells, mesenchymal stromal/stem cells and their derivatives such as osteoblasts are key components of bone marrow (BM) niches. Defining the contribution of BM adipocytes to the hematopoietic stem cell niche remains controversial. While an excess of medullar adiposity is generally considered deleterious for hematopoiesis, an active role for adipocytes in shaping the niche has also been proposed. We thus investigated the consequences of total adipocyte deletion, including in the BM niche, on adult hematopoiesis using mice carrying a constitutive deletion of the gene coding for the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ). We show that Pparg^Δ/Δ lipodyst

SUBMITTER: Wilson A 

PROVIDER: S-EPMC6244608 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature