Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

ABSTRACT:

Purpose

Ibuprofen is the drug of choice for treatment of patent ductus arteriosus (PDA). There is accumulating evidence that current ibuprofen-dosing regimens for PDA treatment are inadequate. We aimed to propose an improved dosing regimen, based on all current knowledge.

Methods

We performed a literature search on the clinical pharmacology and effectiveness of ibuprofen. (R)- and (S)-ibuprofen plasma concentration-time profiles of different dosing regimens were simulated using a population pharmacokinetic model and evaluated to obtain a safe, yet likely more efficacious ibuprofen exposure.

Results

The most effective intravenous ibuprofen dosing in previous clinical trials included a first dose of 20 mg kg^-1 followed by 10 mg kg^-1 every 24 h. Sim

SUBMITTER: Flint RB 

PROVIDER: S-EPMC6244763 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature