Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

ABSTRACT:

Purpose

Medulloblastoma, the most common primary pediatric malignant brain tumor, originates in the posterior fossa of the brain. Pineoblastoma, which originates within the pineal gland, is a rarer malignancy that also presents in the pediatric population. Medulloblastoma and pineoblastoma exhibit overlapping clinical features and have similar histopathological characteristics. Histopathological similarities confound rapid diagnoses of these two tumor types. We have conducted a pilot feasibility study analyzing the molecular profile of archived frozen human tumor specimens using mass spectrometry imaging (MSI) to identify potential biomarkers capable of classifying and distinguishing between medulloblastoma and pineoblastoma.

Methods

We performed matrix-assisted laser desorp

SUBMITTER: Clark AR 

PROVIDER: S-EPMC6244779 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature