Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study.

ABSTRACT: PURPOSE:We investigated the associations of components of the alternative (C3, C3a, Bb, factor D [FD], factor H [FH], properdin) and the classical complement pathway (C4, C1q, C1-inhibitor [C1-INH]) with prevalent and incident metabolic syndrome in a cohort with a moderately increased risk of cardiometabolic disease. METHODS:The study cohort was comprised of 574 participants (61% men, age 59.6 ± 7.0 years) at baseline and 489 participants after 7-year follow-up. Multiple logistic regression analyses were done to investigate the associations of concentrations of baseline plasma complement (standardized values) with prevalent and incident (in those without metabolic syndrome at baseline, n = 189) metabolic syndrome. RESULTS:C3 (odds ratio (OR) = 1.48 [95% confidence interval: 1.02; 2.14]) an

SUBMITTER: Xin Y 

PROVIDER: S-EPMC6244913 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature