Combination Immune Checkpoint Blockade Strategies to Maximize Immune Response in Gynecological Cancers.

ABSTRACT:

Purpose of review

Immune checkpoint blockade targeting PD-1 and PD-L1 improves immune recognition of tumor cells but had only modest success in gynecological cancers as monotherapy. Growing focus has been placed on combination immunotherapy strategies to overcome this resistance, and this review serves to discuss some of the most promising studies in gynecological cancers.

Recent findings

PD-1- and PD-L1-targeting antibodies are being combined with many novel agents including anti-CTLA-4 antibodies, PARP inhibitors, targeted agents, and traditional chemotherapy in promising studies with the hopes of increasing the immune response and overcoming resistance by targeting other pathways. Novel immune techniques including vaccines and adoptive cell therapies are also being implem

SUBMITTER: Liu YL 

PROVIDER: S-EPMC6244932 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature