2-Deoxy-D-ribose-5-phosphate aldolase (DERA): applications and modifications.

ABSTRACT: 2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is a class I aldolase that offers access to several building blocks for organic synthesis. It catalyzes the stereoselective C-C bond formation between acetaldehyde and numerous other aldehydes. However, the practical application of DERA as a biocatalyst is limited by its poor tolerance towards industrially relevant concentrations of aldehydes, in particular acetaldehyde. Therefore, the development of proper experimental conditions, including protein engineering and/or immobilization on appropriate supports, is required. The present review is aimed to provide a brief overview of DERA, its history, and progress made in understanding the functioning of the enzyme. Furthermore, the current understanding regarding aldehyde resistance of DERA and the

SUBMITTER: Haridas M 

PROVIDER: S-EPMC6244999 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature