Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.

ABSTRACT:

Objective

Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk.

Research design and methods

We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence.

Results

B

SUBMITTER: Razquin C 

PROVIDER: S-EPMC6245212 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature