Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin.

ABSTRACT: Behavior and physiology are orchestrated by neuropeptides acting as central neuromodulators and circulating hormones. An outstanding question is how these neuropeptides function to coordinate complex and competing behaviors. In Drosophila, the neuropeptide leucokinin (LK) modulates diverse functions, but mechanisms underlying these complex interactions remain poorly understood. As a first step towards understanding these mechanisms, we delineated LK circuitry that governs various aspects of post-feeding physiology and behavior. We found that impaired LK signaling in Lk and Lk receptor (Lkr) mutants affects diverse but coordinated processes, including regulation of stress, water homeostasis, feeding, locomotor activity, and metabolic rate. Next, we sought to define the populations of LK neu

SUBMITTER: Zandawala M 

PROVIDER: S-EPMC6245514 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature