Predicting acute kidney injury at hospital re-entry using high-dimensional electronic health record data.

ABSTRACT: Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing studies consider all patients and therefore restrict to features available in the first hours of hospitalization. Here, the focus is instead on rehospitalized patients, a cohort in which rich longitudinal features from prior hospitalizations can be analyzed. Our objective is to provide a risk score directly at hospital re-entry. Gradient boosting, penalized logistic regression (with and without stability selection), and a recurrent neural network are trained on two years of adult inpatient EHR data (3,387 attributes for 34,505 patients who generated 90,01

SUBMITTER: Weisenthal SJ 

PROVIDER: S-EPMC6245516 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature