Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study.

ABSTRACT:

Rationale & objectives

Lower 25-hydroxyvitamin D concentrations have been associated with risk for kidney function decline, heart failure, and mortality. However, 25-hydroxyvitamin D requires conversion to its active metabolite, calcitriol, for most biological effects. The associations of calcitriol concentrations with clinical events have not been well explored.

Study design

Case-cohort study.

Setting & participants

Well-functioning community-living older adults aged 70 to 79 years at inception who participated in the Health, Aging, and Body Composition (Health ABC) Study.

Predictor

Serum calcitriol measured using positive ion electrospray ionization-tandem mass spectrometry.

Outcomes

Major kidney function decline (≥30% decline in estimated glomerular f

SUBMITTER: Selamet U 

PROVIDER: S-EPMC6245577 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature