Comprehensive study of instable regions in Pseudomonas aeruginosa and Mycobacterium tuberculosis.

ABSTRACT:

Background

Pseudomonas aeruginosa is a common bacterium which is recognized for its association with hospital-acquired infections and its advanced antibiotic resistance mechanisms. Tuberculosis, one of the major causes of mortality, is initiated by the deposition of Mycobacterium tuberculosis. Accessory sequences shared by a subset of strains of a species play an important role in a species' evolution, antibiotic resistance and infectious potential.

Results

Here, with a multiple sequence aligner, we segmented 25 P. aeruginosa genomes and 28 M. tuberculosis genomes into core blocks (include sequences shared by all the input genomes) and dispensable blocks (include sequences shared by a subset of the input genomes), respectively. For each input genome, we then constructed a sc

SUBMITTER: Wang D 

PROVIDER: S-EPMC6245595 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature