Automated selection of homologs to track the evolutionary history of proteins.

ABSTRACT:

Background

The selection of distant homologs of a query protein under study is a usual and useful application of protein sequence databases. Such sets of homologs are often applied to investigate the function of a protein and the degree to which experimental results can be transferred from one organism to another. In particular, a variety of databases facilitates static browsing for orthologs. However, these resources have a limited power when identifying orthologs between taxonomically distant species. In addition, in some situations, for a given query protein, it is advantageous to compare the sets of orthologs from different specific organisms: this recursive step-wise search might give an idea of the evolutionary path of the protein as a series of consecutive steps, for example

SUBMITTER: Mier P 

PROVIDER: S-EPMC6245638 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature