Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction.

ABSTRACT:

Background

Neuraxial modulation with cardiac sympathetic denervation (CSD) can potentially reduce burden of ventricular tachyarrhythmia (VT). However, despite catheter ablation and CSD, VT can recur in patients with cardiomyopathy and the role of vagal nerve stimulation (VNS) in this setting is unclear.

Objective

The purpose of this study was to evaluate the electrophysiological effects of VNS after CSD in normal and infarcted hearts.

Methods

In 10 normal and 6 infarcted pigs, electrophysiological and hemodynamic parameters were evaluated before and during intermittent VNS pre-CSD (bilateral stellectomy and T2-T4 thoracic ganglia removal) as well as post-CSD. The effect of VNS during isoproterenol was also assessed pre- and post-CSD. Multielectrode ventricular activat

SUBMITTER: Yamaguchi N 

PROVIDER: S-EPMC6245660 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature