TIMP-1 is a novel serum biomarker for the diagnosis of colorectal cancer: A meta-analysis.

ABSTRACT:

Purpose

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a glycoprotein involved in cell survival and tumorigenesis. There have been some promising results regarding the diagnostic value of TIMP-1 for patients with colorectal cancer (CRC). The aim of the present study was to assess the diagnostic accuracy and clinical utility of serum TIMP-1 in CRC patients through meta-analysis.

Methods

A systematic search of online databases was performed to collect eligible studies. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operator characteristic (SROC) curve were generated from accuracy data using the random-effects model. Fagan's nomogram and the likelihood matrix were applied to estimate the clinical utility of TIMP-1.

Results

A t

SUBMITTER: Meng C 

PROVIDER: S-EPMC6245680 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature