Large scale study of anti-sense regulation by differential network analysis.

ABSTRACT:

Background

Systems biology aims to analyse regulation mechanisms into the cell. By mapping interactions observed in different situations, differential network analysis has shown its power to reveal specific cellular responses or specific dysfunctional regulations. In this work, we propose to explore on a large scale the role of natural anti-sense transcription on gene regulation mechanisms, and we focus our study on apple (Malus domestica) in the context of fruit ripening in cold storage.

Results

We present a differential functional analysis of the sense and anti-sense transcriptomic data that reveals functional terms linked to the ripening process. To develop our differential network analysis, we introduce our inference method of an Extended Core Network; this method is ins

SUBMITTER: Legeay M 

PROVIDER: S-EPMC6245689 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature