Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial.

ABSTRACT:

Background

We sought to determine the effects of alternative resuscitation strategies on microcirculatory perfusion and examine any association between microcirculatory perfusion and mortality in sepsis.

Methods

This was a prospective, formally designed substudy of participants in the Protocolized Care in Early Septic Shock (ProCESS) trial. We recruited from six sites with the equipment and training to perform these study procedures. All subjects were adults with septic shock, and each was assigned to alternative resuscitation strategies. The two main analyses assessed (1) the impact of resuscitation strategies on microcirculatory perfusion parameters and (2) the association of microcirculatory perfusion with 60-day in-hospital mortality. We measured sublingual microcirculat

SUBMITTER: Massey MJ 

PROVIDER: S-EPMC6245723 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature