Serum uromodulin and progression of kidney disease in patients with chronic kidney disease.

ABSTRACT:

Background

Uromodulin is specifically synthesized and secreted by kidney tubular epithelial cells. Studies on the association of serum uromodulin and outcomes of chronic kidney disease (CKD) are lacking. This study aimed to evaluate whether serum uromodulin was associated with outcomes of patients with CKD.

Methods

We measured serum uromodulin concentrations by ELISA in 2652 CKD patients from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) and investigated the association of serum uromodulin with outcomes of CKD patients, including end-stage kidney disease (ESKD) receiving kidney replacement therapy, cardiovascular events and mortality by Cox proportional hazards regression model.

Results

A total of 2652 CKD patients were enrolled in this study, with an

SUBMITTER: Lv L 

PROVIDER: S-EPMC6245763 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature