The influence of maternal pregnancy glucose concentrations on associations between a fetal imprinted gene allele score and offspring size at birth.

ABSTRACT:

Objective

Previously we found that certain fetal imprinted genes represented as an allele score are associated with maternal pregnancy glucose concentrations. Recently it was reported that fetal polymorphisms with strong associations with birth weight tend to mediate these independently of increases in maternal pregnancy glucose concentrations. We therefore investigated whether potential associations between the fetal allele score and birth weight were related to maternal glucose concentrations in the Cambridge Baby Growth Study.

Results

The fetal imprinted gene allele score was positively associated with birth weight (β = 63 (17-109) g/risk allele, β' = 0.113, p = 7.6 × 10^-3, n = 405). This association was partially attenuated by adjusting for maternal glucose co

SUBMITTER: Petry CJ 

PROVIDER: S-EPMC6245772 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature