Epigenetic outlier profiles in depression: A genome-wide DNA methylation analysis of monozygotic twins.

ABSTRACT: Recent discoveries highlight the importance of stochastic epigenetic changes, as indexed by epigenetic outlier DNA methylation signatures, as a valuable tool to understand aberrant cell function and subsequent human pathology. There is evidence of such changes in different complex disorders as diverse as cancer, obesity and, to a lesser extent, depression. The current study was aimed at identifying outlying DNA methylation signatures of depressive psychopathology. Here, genome-wide DNA methylation levels were measured (by means of Illumina Infinium HumanMethylation450 Beadchip) in peripheral blood of thirty-four monozygotic twins informative for depressive psychopathology (lifetime DSM-IV diagnoses). This dataset was explored to identify outlying epigenetic signatures of depression, operat

SUBMITTER: Cordova-Palomera A 

PROVIDER: S-EPMC6245788 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature