Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.

ABSTRACT:

Background

Because driver mutations provide selective advantage to the mutant clone, they tend to occur at a higher frequency in tumor samples compared to selectively neutral (passenger) mutations. However, mutation frequency alone is insufficient to identify cancer genes because mutability is influenced by many gene characteristics, such as size, nucleotide composition, etc. The goal of this study was to identify gene characteristics associated with the frequency of somatic mutations in the gene in tumor samples.

Results

We used data on somatic mutations detected by genome wide screens from the Catalog of Somatic Mutations in Cancer (COSMIC). Gene size, nucleotide composition, expression level of the gene, relative replication time in the cell cycle, level of evolutionary c

SUBMITTER: Gorlov IP 

PROVIDER: S-EPMC6245819 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature