Predictive value of lymphocyte-to-monocyte ratio in the preoperative setting for progression of patients with breast cancer.

ABSTRACT:

Background

The lymphocyte-to-monocyte ratio (LMR) has been used as a parameter reflecting systemic inflammation in several tumors, and is reportedly associated with prognosis in cancer patients. In this study, we evaluated the predictive value of LMR for progression and chemosensitivity in breast cancer patients treated with preoperative chemotherapy.

Methods

LMR was evaluated in 239 patients with breast cancer treated with neoadjuvant chemotherapy (NAC) with 5-fluorouracil, epirubicin, and cyclophosphamide, followed by weekly paclitaxel with or without trastuzumab, and subsequent curative surgery. The correlations between LMR and clinicopathological features, prognosis, and pathological complete response (pCR) rate of NAC were evaluated retrospectively. We also evaluated th

SUBMITTER: Goto W 

PROVIDER: S-EPMC6245848 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature