The Impact of Using Different Reference Populations on Measurement of Breast Cancer-Related Cognitive Impairment Rates.

ABSTRACT:

Objective

To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates.

Methods

Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function. Domain-specific impairment was defined as having one test score 2 SD below or two or more test scores 1.5 SD below the reference population means. Different reference populations were used to define impairment: published normative data, study-specific controls, age and education-stratified controls, and ag

SUBMITTER: Clapp JD 

PROVIDER: S-EPMC6246339 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature