SIGNIFICANT GENE-GENE INTERACTION OF TNF-α AND VDR ON OSTEOPOROSIS COMMUNITY-DWELLING ELDERS

ABSTRACT: Abstract Osteoporosis (OST) is a complex multifactorial disease. Prior studies evaluated gene effects seperately on OST. We evaluated gene-gene interactions of polymorphisms in tumor necrosis factor-α (TNF-α) and vitamin D receptor (VDR) genes on OST in elders. A total of 472 elders were included from Taichung Community Health Study for Elders; polymorphisms (TNF-α: rs1799964, rs1800629, rs3093662; VDR: rs7975232, rs1544410, rs2239185, rs3782905) were genotyped. Bone mineral densities (BMD) of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured by DEXA. Overall and site-specific OSTs were defined as BMD T-score ≤ − 2.5 standard deviations. Predictive models’ ability to discriminate OST status was evaluated by areas under the receiver operating characteristics (AUROC) cur

SUBMITTER: Liao L 

PROVIDER: S-EPMC6246352 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature