Impaired COMMD10-Mediated Regulation of Ly6C^hi Monocyte-Driven Inflammation Disrupts Gut Barrier Function.

ABSTRACT: Ly6C^hi monocyte tissue infiltrates play important roles in mediating local inflammation, bacterial elimination and resolution during sepsis and inflammatory bowel disease (IBD). Yet, the immunoregulatory pathways dictating their activity remain poorly understood. COMMD family proteins are emerging as key regulators of signaling and protein trafficking events during inflammation, but the specific role of COMMD10 in governing Ly6C^hi monocyte-driven inflammation is unknown. Here we report that COMMD10 curbs canonical and non-canonical inflammasome activity in Ly6C^hi monocytes in a model of LPS-induced systemic inflammation. Accordingly, its deficiency in myeloid cells, but not in tissue resident macrophages, resulted in increased Ly6C^hi monocyte liv

SUBMITTER: Mouhadeb O 

PROVIDER: S-EPMC6246736 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature