Applying lessons from human papillomavirus vaccines to the development of vaccines against Chlamydia trachomatis.

ABSTRACT:

Introduction

Chlamydia trachomatis (Ct), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility, and ectopic pregnancy in women. In this Perspective, we discuss the successful human papillomavirus (HPV) vaccine as a case study to inform Ct vaccine efforts. Areas covered: The immunological basis of HPV vaccine-elicited protection is high-titer, long-lasting antibody responses in the genital tract which provides sterilizing immunity. These antibodies are elicited through parenteral administration of a subunit vaccine based on virus-like particles (VLPs) of HPV. We present three lessons learned from the successful HPV vaccine efforts: (1) antibodies alone can be sufficient to provide protection from STIs in the genital tract,

SUBMITTER: Frietze KM 

PROVIDER: S-EPMC6246778 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature