Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.

ABSTRACT:

Objective

The classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. Our aim was to examine baseline characteristics of DEP-CI patients in the DOTCODE trial, a randomized controlled trial of open antidepressant treatment for 16 weeks followed by add-on donepezil or placebo for 62 weeks.

Methods/design

Key inclusion criteria were diagnosis of major depression or dysthymic disorder with Hamilton Depression Rating Scale (HAM-D) score >14, and cognitive impairment defined by MMSE score ≥21 and impaired performance on the WMS-R Logical Memory II

SUBMITTER: Motter JN 

PROVIDER: S-EPMC6246783 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature