Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4⁺ T Cell Activation.

ABSTRACT: Activation of CD4⁺ T cells to proliferate drives cells toward aerobic glycolysis for energy production while using mitochondria primarily for macromolecular synthesis. In addition, the mitochondria of activated T cells increase production of reactive oxygen species, providing an important second messenger for intracellular signaling pathways. To better understand the critical changes in mitochondria that accompany prolonged T cell activation, we carried out an extensive analysis of mitochondrial remodeling using a combination of conventional strategies and a novel high-resolution imaging method. We show that for 4 d following activation, mouse CD4⁺ T cells sustained their commitment to glycolysis facilitated by increased glucose uptake through increased expression of

SUBMITTER: Akkaya B 

PROVIDER: S-EPMC6246812 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature