Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

ABSTRACT:

Purpose

To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement.

Design

Prospective cohort study within a controlled clinical trial.

Participants

Age-Related Eye Disease Study 2 (AREDS2) participants, aged 50-85 years.

Methods

Baseline and annual stereoscopic color fundus photographs were evaluated for GA presence and area. Analyses included GA prevalence and incidence rates, Kaplan-Meier rates, mixed-model regression, and multivariable analysis of the square root of GA, area adjusted for covariates, including clinical/imaging characteristics and genotype.

Main outcome measures

(1) Presence or development

SUBMITTER: Keenan TD 

PROVIDER: S-EPMC6246813 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature