Repeated Failure in Reward Pursuit Alters Innate Drosophila Larval Behaviors.

ABSTRACT: Animals always seek rewards and the related neural basis has been well studied. However, what happens when animals fail to get a reward is largely unknown, although this is commonly seen in behaviors such as predation. Here, we set up a behavioral model of repeated failure in reward pursuit (RFRP) in Drosophila larvae. In this model, the larvae were repeatedly prevented from reaching attractants such as yeast and butyl acetate, before finally abandoning further attempts. After giving up, they usually showed a decreased locomotor speed and impaired performance in light avoidance and sugar preference, which were named as phenotypes of RFRP states. In larvae that had developed RFRP phenotypes, the octopamine concentration was greatly elevated, while tβh mutants devoid of octopamine were less

SUBMITTER: Fei Y 

PROVIDER: S-EPMC6246844 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature