Integrated analysis of long noncoding RNA interactions reveals the potential role in progression of human papillary thyroid cancer.

ABSTRACT: Recent scientific evidence has suggested that long noncoding RNAs (lncRNAs) play an important part in tumorigenesis as an important member of competing endogenous RNAs (ceRNAs). Hundreds of RNA sequence data and relevant clinic information are freely accessible in The Cancer Genome Atlas (TCGA) datasets. However, the role of cancer-related lncRNAs in papillary thyroid cancer (PTC) is not fully understood yet. In this study, we identified 461 RNA sequencing data from TCGA. Subsequently, 45 lncRNAs, 21 miRNAs, and 78 mRNAs were chosen to construct a ceRNA network of PTC. Then, we analyzed the correlation between these 45 PTC-specific lncRNAs and clinic features and patient outcome. Thirty-seven of these lncRNAs were found to be closely related to age, race, gender, lymph node metastasis, TNM

SUBMITTER: You X 

PROVIDER: S-EPMC6246933 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature