Would 1.0 cm be a more suitable cutoff to subdivide pT1 tumors in hormone receptor-negative and HER2-positive breast cancer?

ABSTRACT:

Background

HER2+ and hormone receptor (HoR)-negative breast cancer usually associated with poor outcome. However, it remained elusive for the prognosis of small (T1a-T1c) HER2+/HoR- breast cancer. The present study retrospectively analyzed the Surveillance, Epidemiology, and End Results (SEER) database to explore the clinicopathological characteristics and prognosis of T1a-T1c HER2+/HoR- breast cancer.

Material and methods

Data for patients diagnosed with either HER2-/HoR+or HER2+/HoR- T1a-T1c breast cancer between 2010 and 2012 were obtained from SEER program. Survival analyses were conducted by Kaplan-Meier method and Cox proportion hazard regression.

Results

Totally, 2648 HER2+/HoR- and 56387 HER2-/HoR+T1a-T1c breast cancer patients were enrolled. There was a clear

SUBMITTER: Wang C 

PROVIDER: S-EPMC6246936 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature