Effect of functional genetic variants in chemokine decoy receptors on the recurrence risk of breast cancer.

ABSTRACT: Duffy antigen receptor for chemokine (DARC) and CCBP2, the two members of chemokine decoy receptor family, restrain cell proliferation and invasion through sequestrating cytotoxic chemokines. Our previous research clarified two functional nonsynonymous single nucleotide polymorphisms (SNPs): rs12075 in DARC and rs2228468 in CCBP2 were significantly correlated with lymph node metastasis. However, the role of their genetic variations on survival of breast cancer remains unclear. In the present study, rs12075 in DARC and rs2228468 in CCBP2 were genotyped in 806 patients with primary breast cancer. The endpoint was recurrence-free survival (RFS). Cox regression model was used to explore the association between SNPs and patients' survival. The results revealed that participants with GG genotype

SUBMITTER: Li DD 

PROVIDER: S-EPMC6247033 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature