Modification of American Joint Committee on cancer prognostic groups for renal cell carcinoma.

ABSTRACT:

Background

To compare the predictive value of the current AJCC stage grouping for renal cell carcinoma (RCC) to our modifications.

Patients and methods

A total of 2120 patients with RCC from Fudan University Shanghai Cancer Center (FUSCC) database and 74 506 counterparts from SEER database were included. Cox regression was used to calculate the relative impacts between prognostic groups. The predictive accuracy of overall survival (OS) was assessed using the concordance index (C-index), which was compared by likelihood ratio test.

Results

In FUSCC cohort, the 5-year-OS rate for T3N0M0 patients was higher than T1-3N1M0 (72.7% vs 38.1%). The 5-year-OS rate for T4N0M0 was 36.2%, which was close to T1-3N1M0 but not to T4N1M0 (0%) and TanyNanyM1 (12.6%). The elements of AJ

SUBMITTER: Shao N 

PROVIDER: S-EPMC6247054 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature