Dataset Information
Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions.
Ontology highlight
ABSTRACT: Aim
To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions.Methods
Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered.Results
EMR was performed in 11 lesions (46.4 mm ± 4 mm, range 40-70 mm). Delayed bleeding or perforation was not observed in any patient. Mean ulcerated area at baseline was 22.7 cm2 ± 11.7 cm2 whereas at week 4 were 2.9 cm2 ± 1.5 cm2. Patients treated with PRP showed a very high MHR after 4 wk (87.5%).Conclusion
PRP is an easy-to-obtain solution with proven and favourable biological activities that could be used in advanced endoscopic resection.
SUBMITTER: Lorenzo-Zuniga V
PROVIDER: S-EPMC6247099 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Submucosal injection of platelet-rich plasma in endoscopic resection of large sessile lesions.
World journal of gastrointestinal endoscopy 20181101 11
<h4>Aim</h4>To prospectively evaluate the efficacy of submucosal injection of platelet-rich plasma (PRP) on endoscopic resection of large sessile lesions.<h4>Methods</h4>Eleven patients were submitted to endoscopic mucosal resection (EMR) with prior injection of PRP, obtained at the time of endoscopy. Patients were followed during 1 mo. The incidence of adverse events (delayed bleeding or perforation) and the percentage of mucosal healing (MHR) after 4 wk were registered.<h4>Results</h4>EMR was ...[more]