The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.

ABSTRACT: The beneficial effect of anticholinergic therapy for chronic lung diseases such as chronic obstructive pulmonary disease (COPD) is well documented, although cholinergic stimulation paradoxically inhibits liquid absorption, increases ciliary beat frequency and increases airway surface liquid transport.Using pig tracheobronchial explants, we quantified basal mucus transport before as well as after incubation with the clinically used antimuscarinic compound ipratropium bromide (Atrovent) and stimulation with acetylcholine.As expected, surface liquid transport was increased by acetylcholine and carbachol. In contrast, the mucus bundles secreted from the submucosal glands normally transported on the cilia were stopped from moving by acetylcholine, an effect inhibited by ipratropium bromide. Int

SUBMITTER: Ermund A 

PROVIDER: S-EPMC6247115 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature