Utility of the NIH Toolbox for assessment of prodromal Alzheimer's disease and dementia.

ABSTRACT:

Introduction

The NIH Toolbox Cognition Battery (NIHTB-CB) is a computer-based protocol not yet validated for clinical assessment.

Methods

We administered the NIHTB-CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity. Discriminant function analyses compared classification accuracy.

Results

Principal component analysis identified three conceptually coherent factors: memory (MEM_NIH), executive function (EF_NIH), and crystallized inte

SUBMITTER: Hackett K 

PROVIDER: S-EPMC6247399 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature