Leber's hereditary optic neuropathy: Shifting our attention to the macula.

ABSTRACT:

Purpose

Peripapillary vascular alterations have been classically described as hallmarks of Leber's Hereditary Optic Neuropathy (LHON). We recently demonstrated microvascular pathology involving the macula in patients affected with chronic LHON using optical coherence tomography angiography (OCTA). Macular vascular pathology in acute LHON has not previously been reported.

Methods

The macular superficial vasculature of an asymptomatic carrier and an affected patient with acute LHON, mitochondrial DNA mutation 3460, was assessed by OCTA.

Results

Similar findings of peripapillary microangiopathy and vascular telangiectasias were seen the affected patient, but in the parafoveal macula. These changes were most prominent nasally and inferiorly, corresponding to the proximal

SUBMITTER: Asanad S 

PROVIDER: S-EPMC6247405 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature