Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.

ABSTRACT:

Background

Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of histone H3 lysine modifications to learning and memory in Drosophila by using histone lysine-to-alanine mutants.

Results

Behavioural analysis indicated that compared to the H3WT group, mutants overexpressing H3K23A displayed impaired courtship learning. Chromatin immunoprecipitation analysis of H3K23A mutants showed that H3K23 acetylation (H3K23ac) levels were decreased on learning-related genes. Knockdown of CREB-binding protein (CBP) decreased H3K23ac levels, attenuated the expression of learning-related genes, led to a courtship learning defect and altered dev

SUBMITTER: Li KL 

PROVIDER: S-EPMC6247617 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature